Saturday, December 10, 2022

The Problematic Paradigm of LDL-C, Introduction

 

As was mentioned in this blog’s introductory post, much of what will be written on here will be expansive pieces on health and nutrition, designed to be both in-depth but also accessible to somebody with no background in topics related to health, physiology, or nutrition. Future topics will likely include, among others – why epidemiology (ie. observational study) is mostly junk science, why meat is certainly not causing cancer, why animals are not driving climate change, various aspects of chronic disease, the relationships between extreme exercise and health, why vegetables oils will lower your cholesterol but probably also contribute to killing you, why vegetables aren’t all they’re cracked up to be, and why your health will likely improve if you eat a bunch of them anyway.

However, the first topic that will be explored, likely over the course of the next 2-3 months, is cholesterol and cardiovascular disease. Cardiovascular disease is probably the most prominent chronic disease in the modern consciousness and the disease at which most dietary and nutrition advice has been aimed over the last several decades. Simply put, I believe the bulk of that advice has been and remains erroneous and actively harmful to those subscribing to its tenants, and has been far more effective at promoting massive commercial and pharmaceutical interests than it has at improving health or preventing disease.

I have already written a lengthy paper on the subject of lipid metabolism, cholesterol, and cardiovascular disease, which can be found here. However, this paper almost certainly suffers from the aforementioned problem of inaccessibility. My hope here, over the next several weeks, is to explain in lay terms the paper’s thesis and its implications for cardiovascular disease and human nutrition. I intend for this to be a roughly ten-part series on all things cholesterol, beginning with the necessary background information before walking through the behavior and mechanics of lipids and the dietary choices that drive these observations. This introductory post will serve as a table of contents of sorts, with part 1 coming shortly.


Part 1 - The Development of the Lipid-Heart and Diet-Heart Hypotheses 

Part 2 - LDL Studies and the Association Between LDL-C and Heart Disease, Pt. 1

Part 3 - LDL Studies and the Association between LDL-C and Heart Disease, Pt. 2

Part 4 - Lipids and Cholesterol: Who Are the Players and What Are We Really Measuring?

Part 5 - An Energy Delivery Model: Triglyceride Production and Utilization

Part 6 - An Energy Delivery Model: The Consequences of Poor Triglycerides Utilization

Part 7 - An Energy Delivery Model: Efficient Triglyceride Uptake and an Increased Energy Demand

Part 8 - An Energy Delivery Model: The Contrasting Presentations of Elevated LDL-C

Part 9 - An Energy Delivery Model: The Downstream Consequences of an Impaired Energy Delivery System

Part 10 - Other Factors in the Development of Atherosclerosis

Part 11 - The Effects of Diet on Markers of Cardiovascular and Metabolic Health

Part 12 - The Effects of Diet on LDL-C, As Told By Energy Delivery







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